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MitoRx Publishes Study on AP39’s Effectiveness in Reducing Obesity

October 17th 2024

MitoRx Therapeutics has published a study in Pharmacological Research demonstrating that its mitochondrial-targeted sulfide-donor compound, AP39, significantly reduces weight gain and fatty liver. This study is the first to explore the potential of mitochondrial sulfide donors in addressing obesity-related disorders.

AP39 was found to reduce weight gain by 32%, lower triglycerides, and decrease inflammatory markers, suggesting it affects lipid metabolism through the mTOR/SREBP-1/SCD1 pathway. MitoRx is developing next-generation compounds that not only combat obesity but also protect muscle, potentially addressing muscle loss associated with existing obesity treatments like GLP-1 receptor agonists.

Dr Jon Rees, CEO of MitoRx, emphasised the importance of this research in providing a new therapeutic avenue for metabolic diseases while mitigating side effects associated with current treatments. The lead author, Dr Aneta Stachowicz, highlighted the significance of this work in advancing innovative treatments for metabolic disorders through the modulation of mitochondrial signalling.

 

To read the full article or to stay up to date with further developments please follow the link – MitoRx Therapeutics Announces Publication Showing Mitochondrial Sulfide Donor AP39 Significantly Alleviates Obesity

October 17th 2025

Connecting our community through The Wire – a new digital platform for innovators

We’re excited to share that Oxford Innovation Space has launched The Wire – a brand-new digital platform created to connect more than 900 businesses across the UK and Ireland that call our innovation centres home. As part of the Oxford Innovation Space network, businesses based here at The Harwell Innovation […]

October 1st 2025

Immigration law firm Migrate UK relocates to Harwell Campus

  Migrate UK has relocated to Harwell Campus, a science and innovation park just outside Chilton that is home to more than 200 organisations. It also hosts 14 leading facilities, including the European Space Agency’s European satellite and space telecommunications centre. Migrate UK’s 12-strong team has joined other businesses at […]

June 13th 2025

Harwell Innovation Centre celebrates 25 years of powering science and technology innovation

Playing a supporting role in the UK’s innovation economy, we at Harwell Innovation Centre in Oxfordshire marked our 25th anniversary on Wednesday (11 June 2025) with a special event honouring the early-stage businesses we have helped nurture – many of which are now leading breakthroughs in energy, space, health and quantum computing. […]