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UK HSA Lecture: Dr Zelikoff
July 26 @ 11:00 am - 12:30 pm
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Health impacts of early life exposure to electronic cigarettes: a toxicological perspective on the offspring
Join us online on Friday 26th July between 11:00-12:30 for a talk by Dr Zelikoff on the health impacts of early life
Dr Zelikoff is a tenure-professor in the Division of Environmental Medicine at the New York University School of Medicine, in New York City. She has >30 years of experience assessing the toxicology of inhaled single contaminants and complex mixtures, including metals, nanoparticles, gaseous and particulate (PM) air pollutants, and smokeless and combustible products from cigarettes, biomass burning, and diesel exhaust. She is a pioneering figure in identifying neurological changes following early life exposure demonstrating the risks associated with maternal “vaping”.
For more than a decade, studies in her laboratory have focused on the effects of early life exposure (prenatal, neonatal and adolescent exposures) to tobacco/nicotine products, including e-cigarettes, smokeless tobacco and conventional cigarettes and particulate air pollution on fetal growth and development, neurobiology and gene expression changes, neuroinflammation and later life adverse offspring outcomes including effects on cognitive behaviour and neuro-inflammation, pulmonary and cardiovascular disease, obesity, immune dysfunction and reproductive success in males and female juvenile and adult offspring.
For example, early life mouse studies carried out in her laboratory demonstrated that adult female offspring of mothers exposed during pregnancy to e-cig aerosols 9with and without nicotine) have increased pulmonary protein levels of fibronectin, LEF-1 and E-cadherin, while age-matched male offspring had decreased E-cadherin, but increased PPARg protein levels. These studies in mice suggest that vaping during pregnancy increases the propensity for later life disease and pulmonary modifications in a sex-dependent manner. Her major contributions and pioneering findings to the field of toxicology and environmental health are associated with the public health implications associated with early life exposure to tobacco/nicotine “smoking” and smokeless products in animal models.
