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MitoRx Publishes Study on AP39’s Effectiveness in Reducing Obesity

October 17th 2024

MitoRx Therapeutics has published a study in Pharmacological Research demonstrating that its mitochondrial-targeted sulfide-donor compound, AP39, significantly reduces weight gain and fatty liver. This study is the first to explore the potential of mitochondrial sulfide donors in addressing obesity-related disorders.

AP39 was found to reduce weight gain by 32%, lower triglycerides, and decrease inflammatory markers, suggesting it affects lipid metabolism through the mTOR/SREBP-1/SCD1 pathway. MitoRx is developing next-generation compounds that not only combat obesity but also protect muscle, potentially addressing muscle loss associated with existing obesity treatments like GLP-1 receptor agonists.

Dr Jon Rees, CEO of MitoRx, emphasised the importance of this research in providing a new therapeutic avenue for metabolic diseases while mitigating side effects associated with current treatments. The lead author, Dr Aneta Stachowicz, highlighted the significance of this work in advancing innovative treatments for metabolic disorders through the modulation of mitochondrial signalling.

 

To read the full article or to stay up to date with further developments please follow the link – MitoRx Therapeutics Announces Publication Showing Mitochondrial Sulfide Donor AP39 Significantly Alleviates Obesity

June 13th 2025

Harwell Innovation Centre celebrates 25 years of powering science and technology innovation

Playing a supporting role in the UK’s innovation economy, we at Harwell Innovation Centre in Oxfordshire marked our 25th anniversary on Wednesday (11 June 2025) with a special event honouring the early-stage businesses we have helped nurture – many of which are now leading breakthroughs in energy, space, health and quantum computing. […]

June 4th 2025

QuEra Computing Opens UK Hub at Harwell Campus to Accelerate Quantum Expansion in Europe

QuEra Computing, a global leader in neutral-atom quantum computing, has opened a flagship UK hub at Harwell Science and Innovation Campus to support its growth, commercialisation efforts, and technology development across the UK and Europe. QuEra has taken over 3,500 sq. ft in Tech Foundry, a new high-specification Tech Box, […]

April 9th 2025

Welcome to April’s Innovation Insights

Get ready for a power-packed newsletter that’s here to fuel your business growth and success! Whether you’re a start-up founder, small business owner, or seasoned entrepreneur, we’ve got something special in store just for you. Our workshops and events will cover a wide range of topics, helping you achieve your […]